Content - SAKK 65/16

SAKK 65/16 - A Phase I trial with TLD-1, a novel liposomal doxorubicin, in patients with advanced solid tumors

In the SAKK 65/16 trial we will be investigating the safety and tolerability of TLD-1 (Talidox) in patients with advanced solid or metastatic tumors. We also want to define the optimum dose of TLD-1 for subsequent research projects. This will be first time that TLD-1 has been tested in humans in a clinical trial.  

TLD-1 comprises the already successful chemotherapeutic agent doxorubicin, to which a novel kind of coating has been applied. This prevents it from being metabolized prematurely following administration, thus enabling the active substance to be transported to where it is needed in the body. A tumor might thus be attacked without damaging important and sensitive organs unnecessarily and side effects might be reduced.  

This trial has not been activated yet. We expect to open the SAKK 65/16 trial for patient accrual by mid 2018.

Study Chair:

PD Dr med Markus Joerger, Cantonal Hospital of St.Gallen, +41 76 559 10 70